Oncogenic Intelligence: Oncogene, not polymorphism
نویسندگان
چکیده
منابع مشابه
Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.
Two forms of activated BCR/ABL proteins, P210 and P185, that differ in BCR-derived sequences, are associated with Philadelphia chromosome-positive leukemias. One of these diseases is chronic myelogenous leukemia, an indolent disease arising in hematopoietic stem cells that is almost always associated with the P210 form of BCR/ABL. Acute lymphocytic leukemia, a more aggressive malignancy, can be...
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ژورنال
عنوان ژورنال: Nature
سال: 1983
ISSN: 0028-0836,1476-4687
DOI: 10.1038/302476b0